Human respiratory viruses are the most prevalent cause of illness, with high rates of morbidity and mortality all across the world. Common respiratory agents from numerous virus families are the predominant etiological agents of acute respiratory infections (ARIs), according to community-based studies conducted over the last five decades. Viral respiratory disease can be mild or severe, but it is more common in the elderly and new-born. Despite the fact that respiratory viruses cause a wide range of illnesses, there are currently just a few preventive or treatment options. On the other hand, recent advances in respiratory virus molecular and cell biology should pave the way for the creation of effective treatments.